Determining Relevant Low-Level Chemical Exposures for Safety Assessments of Consumer Products
May 20–22, 2019
The Hotel Brussels
▸Summary and Scope of the Workshop
Planned as a 2.5 day workshop, organized under the principles and with the assistance of The Toxicology Forum, this meeting intends to progress towards a broadly accepted framework to assess and position the safety of trace chemicals exposure from consumer products, and in particular from articles and assembled consumer goods. Both experimental-analytical and computational approaches, and how their respective exposure data are realistic and relevant for safety assessments, will be in scope.
▸Workshop Scientific Program Sessions and Goals
The workshop is split into five themes that are noted below. Sessions are scheduled covering the main themes. Each session will be comprised of a mix of invited keynote speakers, with the remaining slots determined through an open call for presentation opportunity for all interested participants. The workshop should allow for different stakeholders with potentially opposing views to present their opinion and lead to a constructive scientific debate.
Topic #1: Advances in Analytical Methods: How to Detect and Quantify Relevant Low-Level Chemical Exposure from All Routes?
- Novel methods for specific constituents and contaminants
- Detecting and quantifying IAS and NIAS
- Test set up that closely mimics in-use exposure (dermal/inhalation/oral)
- Matrix effects
- Extractables and leachables from poorly studied/documented consumer goods and materials
- NIAS and substances formed in situ
- Analytical methods for bio-monitoring
- Approaches for ensuring accuracy and understanding limitations/uncertainties with low-level exposure testing
Topic #2: Experimental and/or Modeling Approaches?
- Use and limitations of both approaches
- Frameworks that combine analytical work with modeling
- High-throughput approaches
- Advances in exposure modeling and validation
- Extraction media/conditions for physiologically relevant extractions
- Proposals for standardized test design and set up
- Sectoral views & Supply chain analysis
Topic #3: Global Databases for Exposure Information
- Public exposure databases and initiatives in different geographies – what’s available?
- Harmonization of information and formats
- Use of large datasets for population modelling
- Obtaining more data from industry
Topic #4: Guidance for Practitioners, Recommendations for Policy Work and Public Communication
- Consumer perception of information on chemical presence (trend for organics/naturals/’chemical-free’)
- Risk versus hazard communication
- Information and transparency requirements for industry on presence of chemicals
- Media guidance
Topic #5: Towards a Risk Assessment Best Practice Framework
Registration for the meeting is currently open. Please use the online system linked to below in order to register for the meeting. A brief breakdown of registration prices appears below. The registration fee includes access to all meeting sessions, meals, receptions, etc. scheduled during the meeting. Please contact Kevin Merritt with any questions or concerns regarding meeting registration.
Registration Rates: (Rates in parentheses reflect pricing after the early registration deadline of April 20, 2019)
Member: $600 / ($700)
Nonmember (Gov., Academic, Non-Profit): $850 / ($1000)
Nonmember (Corporate): $1100 / ($1400)
Speaker (non-Invited): $350
Student/Postdoc: $100 / ($150)
This meeting is made possible by the financial contributions of sponsoring companies. A complete list of sponsors appears below. In addition to registration discounts, marketing opportunities, and increased awareness of your companies products and services, sponsoring the meeting helps to ensure future viability of meetings of this nature, granting a continued venue for dialogue and interaction in this facet of science!
European Chemical Industry Council—Long-Range Research Initiative
ExxonMobil Biomedical Sciences, Inc.
The Coca-Cola Company
Procter & Gamble Company
Housing for the meeting is now open. The Toxicology Forum has reserved a limited blocked of discounted rooms for meeting attendees. Reservations are booked based on a first come first served basis. Please visit the Brussels Meeting Housing Reservations page for additional information on rates and booking.
▸Workshop Background and Importance
Increasingly, toxicologists in both industry and regulatory agencies are challenged to address low-level exposures to chemicals in consumer products. While there have been significant advances in the area of exposure assessment, and some widely recognized frameworks exist (such as those used to evaluate the potential for packaging chemicals to migrate into food, or for building material and medical devices), there are currently no broadly accepted methods for evaluating and quantifying potential consumer exposure from several other consumer products such as textiles, toys, furniture, absorbent hygiene products. Having a basic framework recognized by the global scientific community will provide clarity and transparency in how ‘best practice’ exposure assessments are to be done.
Manufacturers of consumer products are regularly requested to share information on the compounds contained in their products, including providing assurance that certain ingredients and contaminants are not present. Also the increased use of recyclates in support of a ‘circular economy’ may increasingly trigger such questions. This can result in significant challenges for complex formulations/products, especially for chemicals that are not intentionally added (NIAS), or were not disclosed as contaminants by suppliers, but nonetheless could be found when non-physiological extraction and sensitive analytical methods are employed.
Quantifying relevant exposure associated with use of a range of products, and especially solid articles, can require advanced sampling approaches and analytical capability that reasonably mimic those conditions that might occur with actual and foreseeable consumer use. By contrast, some regulatory schemes make extensive use of in-silico (computational) approaches to perform a screening risk assessment. This also raises the question of how analytical and mathematical modelling data can be compared or combined. For both approaches it should also be better defined what are ‘most realistic’, ‘reasonably conservative’ versus ‘exaggerated’ or ‘not practically relevant’ conditions.
▸Who Should Attend and Participate
Individuals involved in quality assurance, analytical, and safety experts from chemical suppliers and producers of consumer good and articles, regulators involved consumer exposure and public health topics, academic experts in exposure and analytical chemistry, contract laboratories, exposure modelers, those interested in risk assessment, risk management, mode-of-action, and/or human relevance of analytical exposure measurements. We also welcome the participation of NGOs and consumer associations, science journalists and social science experts.
Meetings of The Toxicology Forum are open to all interested participants.
▸Products and Materials in Scope
The workshop organizers recognize that certain product categories such as medical devices and foods contact materials already have a great deal of guidance and practice associated them. The organizers hope to address in particular those categories where frameworks are currently less developed or non-existing. These will include; electric/electronic equipment and appliances, household and personal care products, home improvement products, air fresheners, clothes/fabrics/textiles, furniture, toys, 3D-printing materials, recyclates.
The organizing committee is comprised of a number of individuals from the United States and the European Union representing government, academia, and industry.
John Bartzis, PhD
|Silvia Campos, MSc
The Coca Cola Company
|Wolfgang Dekant, PhD
University of Wuerzburg
|Kathie Dionisio, ScD
Suzanne Fitzpatrick, PhD, DABT, ERT
|Eddy Goelen, MS
|Bruno Hubesch, PhD
|Kristin Isaacs, PhD
|Stylianos Kephalopoulos, PhD
|Pim Leonards, PhD
Free University Amsterdam
|Marusia Popovech, PhD, MPH
ExxonMobil Biomedical Sciences
|Amy Roe, PhD, DABT
Procter & Gamble (USA)
|Diederik Schowanek, PhD
Procter & Gamble (BE)
|John Wambaugh, PhD