39th Annual Winter Meeting Agenda


Monday | Tuesday | Wednesday


Monday, January 26, 2015

8:30 AM–12:30 PM The Toxicology Forum Board of Directors Meeting
1:00 PM–1:20 PM Welcoming Remarks from Toxicology Forum President
James Klaunig, Indiana University
1:20 PM–2:00 PM Keynote Lecture: Alzheimer’s Disease Research: Past, Present, and Future
Neil Buckholtz, NIA/NIH
2:00 PM–2:30 PM UPDATE: Seeking Biomarkers and Understanding Mechanisms: Building an Integrated Approach to Risk in Alzheimer's Disease
Madhav Thambisetty, NIA/NIH
2:30 PM–3:00 PM UPDATE: MRI Imaging as a Preclinical Biomarker of Neurotoxicity
Joseph Hanig, US FDA CDER
3:30 PM–4:00 PM UPDATE: Challenges in Assessing the Safety Risks of Innovative Drugs Intended to Treat Alzheimer’s Disease
Carine Kolly, Novartis Institutes of BioMedical Research
4:00 PM–4:30 PM UPDATE: Neurobehavioral Effects of Caffeine
Nancy Wesensten, Walter Reed Army Institute of Research
4:30 PM–5:00 PM UPDATE: Testosterone Therapy: Clinical & Safety Issues
Christine Nguyen, US FDA CDER 
5:30 PM–7:30 PM Welcome Reception
(Included with Registration)


Tuesday, January 27, 2015

7:30 AM–8:30 AM Attendee Breakfast
(Included with Registration)
8:30 AM–12:00 PM SESSION: Waiting for Food Allergen Reference Doses
Moderated by Richard Lane, PepsiCo 
8:30 AM–8:40 AM Introduction and Overview
Joe Levitt, Hogan Lovells 
8:40 AM–9:00 AM The Importance of Reference Doses to Society
Richard Lane, PepsiCo
9:00 AM–9:25 AM Thresholds Based on Population Dose-Distribution Modeling
Joe Baumert, University of Nebraska - Lincoln
9:25 AM–9:50 AM Integrating Dose and Severity of Reaction Into Risk Assessment
Ben Remington, TNO
9:50 AM–10:20 AM BREAK
10:20 AM–10:45 AM Risk Assessment: What Data Gaps Exist?
Steve Taylor, University of Nebraska - Lincoln
10:45 AM–11:10 AM Allergen Thresholds: Regulatory Considerations
Stefano Luccioli, US FDA CFSAN
11:10 AM–12:00 PM Panel Discussion
All Speakers
12:30 PM–12:30 PM 2015 Service Award
Margaret Miller 
12:30 PM–1:30 PM Attendee Luncheon
(Included with Registration)
1:30 PM–5:30 PM SESSION: Use of Genotoxicity Data in Quantitative Risk Assessment: Are We Ready for a Paradigm Shift?
Moderated by Stefan Pfuhler, Procter and Gamble
1:30 PM–2:00 PM Introduction: Quantitative Dose-Response Analysis and Determination of PODs for Genotoxic Effects
Bhaskar Gollapudi, Exponent Inc.
2:00 PM–2:30 PM A Case for Mutagenicity as an Apical Endpoint to Derive Permissible Exposure Levels
Robert Heflich, US FDA
2:30 PM–3:00 PM Case Studies of Genotoxic Agents Acting Through Non-Mutagenic or Non-Linear Types of Mode of Action
David Eastmond, University of California - Riverside
3:00 PM–3:30 PM Analysis of Genotoxicity Dose-Response Data: Pros and Cons of Different Approaches for Deriving Point-of-Departure (PoD) Metrics
Paul White, Health Canada
3:30 PM–4:00 PM BREAK
4:00 PM–4:30 PM Highlights and Learnings from an EEMS/HESI Workshop: From Qualitative Hazard Evaluation to Quantitative Risk Assessment
Stefan Pfuhler, Procter and Gamble
4:30 PM–5:30 PM Moderated Panel Discussion
All Speakers
6:00 PM–9:00 PM Attendee Banquet Dinner
(Included with Registration)


Wednesday, January 28, 2015

7:30 AM–8:30 AM Attendee Breakfast
(Included with Registration)
8:30 AM–10:30 AM SESSION:Efficacy of Low-Calorie Sweeteners
Moderated by Richard Adamson, TPN Associates 
8:30 AM–9:00 AM Evidence for the Inclusion of Non-Nutritive Sweetened Beverages in Weight Loss Programs
Danielle Ostendorf, University of Colorado - Denver
9:00 AM–9:30 AM Are Low-Calorie Sweeteners Helping us Fight the Obesity Epidemic?
Kenneth Williams, University of Texas Health Science Center at San Antonio
9:30 AM–10:00 AM Low-Calorie Sweeteners and Obesity: Summary of the Evidence
Mark Pereira, University of Minnesota School of Public Health
10:00 AM–10:30 AM Moderated Panel Discussion
All Speakers and Richard Adamson, TPN Associates
10:30 AM–11:00 AM
11:00 AM–11:30 AM UPDATE: Effects of Climate Change on Environmental Chemicals
John Balbus, NIEHS
11:30 AM–12:00 PM UPDATE: Dose-Response Evaluation of Health Effects of Partially Hydrogenated Oils (PHOs)
Lynne Haber, Toxicology Excellence for Risk Assessment (TERA)
12:00 PM–12:30 PM UPDATE: Tox21 Survey Review
Patrick Allard, University of California - Los Angeles
12:30 PM–1:30 PM Attendee Luncheon
(Included with Registration)
1:30 PM–5:00 PM SESSION: Debating the Varying Criteria for Incorporating “Mechanistic Data” into Cancer Classification
Moderated by James Bus, Exponent Inc.
1:30 PM–2:00 PM Introduction and Overview
James Bus, Exponent Inc.
2:00 PM–2:30 PM Mechanistic Data, Cellular Pathways and Cancer Classification
Christopher Portier, International Agency for Research on Cancer
2:30 PM–3:00 PM NCTR Perspective on the Incorporation of Mechanistic Data in Cancer Studies
Goncalo Gamboa da Costa, US FDA NCTR
3:00 PM–3:30 PM BREAK
3:30 PM–4:00 PM Varying Criteria for Incorporating Mechanistic Data into Cancer Classification - EPA ORD Perspective
Rita Schoeny, US EPA ORD
4:00 PM–4:30 PM Varying Criteria for Incorporating Mechanistic Data into Cancer Classification - EPA IRIS Perspective
Vincent Cogliano, US EPA IRIS
4:30 PM–5:00 PM Moderated Panel Discussion
All Speakers 
5:00 PM–5:10 PM Closing Remarks
James Klaunig, Toxicology Forum President