42nd Annual Summer Meeting of The Toxicology Forum
Grand America Hotel

Salt Lake City, Utah
 

Sunday | Monday | Tuesday | Wednesday | Thursday

 

Sunday, July 24

1:00 PM - 5:00 PM The Toxicology Forum Board of Directors Meeting
5:30 PM - 7:30 PM Welcome Reception
(Included with Registration)

 


Monday, July 25

7:30 AM - 8:30 AM Attendee Breakfast 
(Included with Registration)
8:30 AM - 8:45 AM Welcoming Remarks from the Toxicology Forum President
James Klaunig, Indiana University
8:45 AM - 9:30 AM Ian Munro Keynote Lecture: Molecules, Mechanisms, and Models:  Alternative Approaches to Risk Assessment
George Daston, Procter & Gamble 
9:30 AM - 12:00 Noon Hot Topic UPDATE Sessions
Emphasizing both product development and toxicity assessment considerations
9:30 AM - 10:00 AM UPDATE: Microbiome Assessment on Toxicology Studies
Carl Cerniglia, US FDA-NCTR 
10:00 AM - 10:30 AM BREAK
10:30 AM - 11:00 AM UPDATE: Safety Assessment of Nanomaterial Products
Anil Patri, US FDA-NCTR 
11:00 AM - 11:30 AM UPDATE: Prediction of Efficacy and Safety of Tyrosine-Kinase Inhibitors
William Mattes, US FDA-NCTR 
11:30 AM - 12:00 Noon UPDATE: Liquid Biopsies to Further the Development of Lung Cancer-Based Precision Medicine
Donald Johann, University of Arkansas for Medical Science
12:00 Noon - 1:00 PM Attendee Luncheon
(Included with Registration)
1:00 PM - 1:30 PM The Toxicology Forum Annual Business Meeting
1:30 PM - 5:30 PM SESSION: Bioactive Nutrients - Time for Tolerable Upper Intake Levels to Address Safety
Moderated by James Griffiths
1:30 PM - 1:45 PM Emerging Interest in Dietary Guidance for Bioactive Substances and Efforts to Address Safety Frameworks to Date
James Griffiths, Council for Responsible Nutrition
1:45 PM - 2:25 PM Past and Current Frameworks Used to Establish Tolerable Upper Intake Levels
Alison Yates, Institute of Medicine - Food and Nutrition Board
2:25 PM - 3:05 PM Lutein: A Bioactive Case Study for Safety and Efficacy
John Erdman, University of Illinois at Urbana-Champaign
3:05 PM - 3:35 PM  BREAK
3:35 PM - 4:15 PM EGCG: Friend or Foe?
Andrew Shao, Herbalife
4:15 PM - 4:55 PM Safety of Bioactives: Application of Toxicology Decision-Making and Risk Assessment in Recommending Tolerable Upper Intake Levels for Bioactives
Laurie Dolan, Burdock Group
4:55 PM - 5:30 PM Moderated Panel Discussion

 

Tuesday, July 26

7:30 AM - 8:30 AM Attendee Breakfast 
(Included with Registration)
8:30 AM - 10:30 AM SESSION: IARC Cancer Assessments:  Hazard and Exposure Assessments, and Risk Considerations for Regulated Pesticidal Compounds
Moderated by Janet Collins
8:30 AM - 8:40 AM Session Introduction
Janet Collins, CropLife America 
8:40 AM - 9:05 AM Methodology and Meaning of IARC Hazard Assessment
John McLaughlin, Public Health Ontario
9:05 AM - 9:30 AM Implications of the Use of Epidemiologic Data in Risk Analysis
John Acquavella, Aarhaus University
9:30 AM - 10:00 AM Glyphosate Hazard and Risk Assessment:  A Comparison of the Approaches of Two International Agencies
David Eastmond, University of California - Riverside 
10:00 AM - 10:30 AM Moderated Panel Discussion
10:30 AM - 11:00 AM BREAK
11:00 AM - 1:00 PM SESSION: The Expanding Universe of Structure-Based Decision Trees in Toxicology
Moderated by Antonia Mattia
11:00 AM - 11:30 AM Recent Changes in the Decision Tree and the JECFA Procedure for the Safety Evaluation of Flavoring Substances
Angelika Tritscher, World Health Organization
11:30 AM - 12:00 Noon Advances in the Cramer Decision Tree Classification Schema
Timothy Adams, US FDA-CFSAN
12:00 Noon - 12:30 PM Safety Evaluation of Mixures: A Decision Tree Approach - Case Study of Herbal Supplements
Szabina Stice, US FDA-CFSAN
12:30 PM - 1:00 PM Moderated Panel Discussion
1:00 PM - 2:00 PM Attendee Luncheon
(Included with Registration)
2:00 PM - 2:30 PM UPDATE: Organization and Review of Mechanistic Data According to  "Ten Key Characteristics of Carcinogens” (TKCC)
Susan Borghoff, ToxStrategies, Inc.
2:30 PM - 3:00 PM UPDATE: The Frank R. Lautenberg Chemical Safety for the 21st Century Act: Implications for Chemical Prioritization and Assessment
Jeff Morris, US EPA (Remote)
3:00 PM  Networking and Discussion Session

 

Wednesday, July 27

7:30 AM - 8:30 AM Attendee Breakfast
(Included with Registration)
8:30 AM - 12:15 PM SESSION: Metabolic Disruptors and Metabolic Disruption
Moderated by Jerrold Heindel
8:30 AM - 8:50 AM Role of Metabolism Disruptors in the Susceptibility to Obesity, Type 2 Diabetes, and Liver Lipid Disorders
Jerrold Heindel, NIEHS-DERT
8:50 AM - 9:20 AM Towards a Mechanistic Understanding of How Obesogen Exposure Leads to a Transgenerational Predisposition to Obesity and Fatty Liver
Bruce Blumberg, University of California - Irvine
9:20 AM - 9:50 AM The Paradox of Progress:  Environmental Chemicals and the Origins of Diabetes 
Robert Sargis, University of Chicago
9:50 AM - 10:20 AM Polychlorinated Biphenyls Disrupt Hepatic Metabolism and Regulate Inflammation in Nonalcoholic Steatohepatitis
Matthew Cave, University of Louisville
10:20 AM - 10:50 AM BREAK
10:45 AM - 11:20 AM High-Throughput Screening Methods for Identifying and Prioritizing Chemicals As Metabolism Disruptors 
Kristina Thayer, NIEHS-NTP (Remote)
11:20 AM - 11:30 AM Integration and Future Directions
Jerrold Heindel, NIEHS-DER
11:30 AM - 12:15 PM Moderated Panel Discussion
12:15 PM - 12:45 PM George H. Scott Award Presentation and Lecture
Wolfgang Dekant, University of Würzberg
12:45 PM - 1:30 PM Attendee Luncheon
(Included with Registration)
1:30 PM - 5:00 PM SESSION: The Pursuit of Quality and Objectivity in Risk Assessment
Moderated by Nancy Beck and Suzie Fitzpatrick
1:30 PM - 2:00 PM Correct Science for Regulatory Decisions and Public Health and Its Challenges in the Policy-Making Arena
Stuart Shapiro, Rutgers University
2:00 PM - 2:30 PM Key Elements to Evaluate the Quality of a Risk Assessment
Penelope Fenner-Crisp, Independent Consultant
2:30 PM - 3:00 PM Quality Assurance and the Implementations of NRC Recommendations at the US EPA
Thomas Sinks, US EPA 
3:00 PM - 3:10 PM How the US FDA Ensures Quality in Its Assessments
Antonia Mattia, US FDA-CFSAN
3:10 PM - 3:40 PM BREAK
3:40PM - 3:50 PM How the Utah DEQ Ensures Quality in Its Assessments
Steven Packham, Utah Department of Environmental Quality
3:50 PM - 4:00 PM New Approaches for Evaluating Quality in Risk Assessments
Dima Yazji Shamoun, University of Texas at Austin
4:00 PM - 4:10 PM Ensuring Quality of Risk Assessments in Industry
Jeffrey Lewis, ExxonMobil Biomedical Sciences
4:10 PM - 5:00 PM Moderated Panel Discussion
6:00 PM Attendee Dinner
(Included with Registration) 

 

Thursday, July 28

7:30 AM - 8:30 AM Attendee Breakfast 
(Included with Registration)
8:30 AM - 12:00 Noon SESSION: Refined Applications of Toxicogenomics in Safety Assessment
Moderated by Alison Harrill
8:30 AM - 9:10 AM Past Successes and Pitfalls of Toxicogenomics in Human Health Risk Assessment, and Where We Are Today
Alison Harrill, University of Arkansas for Medical Sciences
9:10 AM - 9:45 AM Unbiased Approaches to Identify Mode of Action in Safety Assessment of Drugs 
James Stevens, Eli Lilly & Company
9:45 AM - 10:15 AM BREAK
10:15 AM - 10:50 AM Tiered Testing for Chemical Risk Assessment at the US EPA Using Genomic Signatures
Matt Martin, US EPA
10:50 AM - 11:20 AM Case Study on the Application of Toxicogenomics in Cancer Risk Assessment 
Jiri Aubrecht, Pfizer 
11:20 AM - 12:00 Noon Moderated Panel Discussion
12:00 Noon Closing Remarks
James Klaunig, Indiana University