40th Summer Meeting Agenda

**The titles link to the presentations.  Access to the presentations is restricted to attendees of the meeting.**

Sunday | Monday | Tuesday | Wednesday | Thursday

Sunday, July 6, 2014

12:30 PM–4:00 PM Board of Directors Meeting
(lunch provided)

4:00 PM–6:00 PM Winter Program Planning

6:00 PM–8:00 PM Attendee Reception
(Spouse Registration Available)


Monday, July 7, 2014

7:30 AM–8:30 AM Attendee Breakfast
8:30 AM–8:45 AM Welcome Address
Richard W. Lane, Vice President of Administration, The Toxicology Forum

8:45 AM–9:30 AM George H. Scott Memorial Award
William Slikker Jr., NCTR, US FDA

9:30 AM–12:10 PM New Approaches to Identify Adaptive/Adverse Responses
Moderated by James E. Klaunig, Indiana University
9:30 AM–9:50 AM Introduction, Stage Setting, Theme
James E. Klaunig, Indiana University
9:50 AM–10:20 AM Liver As a Model System
José E. Manautou, University of Connecticut
10:20 AM–10:50 AM Break
10:50 AM–11:20 AM Adverse Outcome Pathways and Use in Identifying Adverse Response
Daniel Villeneuve, US EPA
11:20 AM–11:50 AM Use of New Tools in Assessment of Adaptive/Adverse Response and Risk Assessment
Russell Thomas, US EPA
11:50 AM–12:10 PM Moderated Panel Discussion
All Speakers
12:10 PM–1:10 PM Attendee Lunch

1:10 PM–1:30 PM Update: HESI RISK21  
Timothy Pastoor, Syngenta
1:30 PM–4:30 PM Caffeine: Critical Science Issues and Public Health Consequences
Moderated by Richard Adamson, American Beverage Association
1:30 PM–2:00 PM Issues Raised over the Past Year
James R. Coughlin, Consultant
2:00 PM–2:30 PM Metabolism and Pharmacokinetics of Caffeine
John R. White, Washington State University
2:30 PM–3:00 PM The Pregnancy Signal and Human Development and Reproductive Studies 
Dominik D. Alexander, EpidStat Institute
3:00 PM–3:30 PM Break
3:30 PM–4:00 PM Remarks on the Letigen Study 
Jay Murray, Murray and Associates
4:00 PM–4:30 PM Moderated Panel Discussion
All Speakers and Jay Murray, Consultant and Antonia Mattia, CFSAN, US FDA

4:30 PM–4:50 PM Update: CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity)
Luisa Camacho, NCTR, US FDA


Tuesday, July 8, 2014

7:00 AM–8:00 AM Attendee Breakfast

8:00 AM–11:00 AM Mouse Lung Tumors
Moderated by Susan Felter, Procter & Gamble
8:00 AM–8:30 AM Introduction: Mouse Lung Tumors: Proposal for a Unified MoA for Compounds Metabolized by CYP2F2
James S. Bus, Exponent Inc.
8:30 AM–9:00 AM Comparison of Mouse and Human Lung; Biological MOA for Mouse Lung Species Differences,
Susceptibility, and Tumorigenesis

Laura Van Winkle, University of California, Davis
9:00 AM–9:30 AM Styrene Case Study Mouse Lung Tumor Mode of Action for Styrene: Lung-CYP2F2-Generated Metabolites
George Cruzan, ToxWorks
9:30 AM–10:00 AM Break
10:00 AM–10:30 AM US Environmental Protection Agency Workshop—Review of the 2014 EPA Mouse Lung Tumor Workshop:
Applying Knowledge to Chemical-Specific Health Risk Assessments

George Woodall, US EPA
10:30 AM–11:00 AM Moderated Panel Discussion
All Speakers

11:00 AM–11:30 AM The IRIS Program: Enhancements, Opportunities, and Scientific Challenges
Vincent Cogliano, US EPA

11:30 AM–12:30 PM Attendee Lunch

12:30 PM–1:15 PM Update: Establishing Thresholds for Allergens
12:30 PM–1:00 PM Scientific Perspective 
Joseph Baumert, University of Nebraska-Lincoln
1:00 PM–1:15 PM Discussion

1:15 PM–1:35 PM Update: Perchlorate Health Risks: Using Computational Models to Address Endocrine Disruption
in the Pregnant Woman and Infant

Jeffrey Fisher, NCTR, US FDA
1:35 PM–2:00 PM Update: Plausibility of Estrogenic Mechanisms for Bisphenol A Evaluated using Dosimetry from Animal Bioassays and Human Biomonitoring
Daniel R. Doerge, NCTR, US FDA
2:00 PM–5:00 PM Fishbowl Interactive Session: Shaping the Future of the Forum
2:00 PM–2:10 PM Introduction
Richard W. Lane, Vice President of Administration, The Toxicology Forum
2:10 PM–2:20 PM History of the Forum
J. David Miller, Carleton University
2:20 PM–2:30 PM Value of the Forum
Fred H. Stults, Givaudan Flavors Corp.
2:30 PM–2:45 PM Break
2:45 PM–5:00 PM Open Discussion
Moderated by James S. Bus, Exponent Inc.

5:00 PM–6:00 PM Members Meeting

6:00 PM–7:00 PM Friends of George Scott Assembly

7:00 PM Attendee Reception/Dinner
(Spouse Registration Available)


Wednesday, July 9, 2014

7:00 AM–8:00 AM Attendee Breakfast

8:00 AM–11:30 AM Biological Correlations and Associations: How Do We Improve Analysis and Interpretation
for Regulatory Decision Making?

Moderated by Robert A. Barter, ExxonMobil
8:00 AM–8:30 AM Background
Harvey J. Clewell, The Hamner Institutes for Health Sciences
8:30 AM–9:00 AM A Need for More Robust Data in Environmental Epidemiology: BPA As a Case Study
Judy S. Lakind, Lakind Associates
9:00 AM–9:30 AM Physiological Factors Affecting Associations
Lesa L. Aylward, Summit Toxicology
9:30 AM–10:00 AM Break
10:00 AM–10:30 AM Reverse Causality
Matthew P. Longnecker, NIEHS
10:30 AM–11:00 AM Moderated Panel Discussion
All Speakers

11:00 AM–1:00 PM Designing a Surveillance Strategy for Food Ingredients
Moderated by Antonia Mattia, US FDA
11:00 AM–11:30 AM The History of Surveys and Their Importance
Thomas Vollmuth, Wrigley
11:30 AM–12:00 Noon Best Practices for Data Collection and Reassessment Prioritization
Timothy Adams, US FDA Consultant
12:00 Noon–12:30 PM Value to Industry and Industry’s Responsibilities
Richard W. Lane, PepsiCo
12:30 PM–1:00 PM Moderated Panel Discussion
All Speakers

  Lunch on own


Thursday, July 10, 2014

7:00 AM–8:00 AM Attendee Breakfast

8:00 AM–1:30 PM Protein and RNAi Technologies in Agriculture
Moderated by Margaret Miller
8:00 AM–8:10 AM Session Introduction
James Sherman, Monsanto Company
8:10 AM–8:40 AM Introduction to Proteins in Agricultural Biotechnology (GMOs)
James Sherman, Monsanto Company
8:40 AM–9:10 AM Safety Assessment of First Generation GMOs: Regulatory Perspective
Supratim Choudhuri, CFSAN, US FDA
9:10 AM–9:40 AM Introduction to the Transformative Technology of RNAi: How RNAI Is Being Used
in Agricultural Biotechnology

Tichafa Munyikwa, Syngenta Biotechnology Inc.
9:40 AM–10:00 AM Break
10:00 AM–10:30 AM Are Ingested Small RNAs from Plants Significantly Absorbed by Humans?
Stephen Y. Chan, Harvard University
10:30 AM–11:00 AM Mammalian Biological Barriers to Absorption of Ingested dsRNA
Jay S. Petrick, Monsanto Company
11:00 AM–11:30 AM Human Health Considerations for RNAi-Based Pesticides: Reflections on the US EPA, SAP,
and EFSA Panel Deliberations

Kenneth Witwer, The Johns Hopkins University
11:30 AM–11:45 AM Attendee Lunch Pickup
11:45 AM–12:30 PM Impact of the Food Wars on Agricultural Biotechnology: Communicating the Science
John L. Vicini, Monsanto Company
12:30 PM–1:00 PM US FDA Regulatory Perspectives
Supratim Choudhuri, CFSAN, US FDA
1:00 PM–1:30 PM Moderated Panel Discussion
All Speakers

  Meeting Adjourned