40th Annual Winter Meeting of The Toxicology Forum
Hotel Monaco

Washington, DC

Monday | Tuesday | Wednesday

All Sessions and Breaks will be held in the Paris Ballroom
All Attendee Meals & Events will be held in the Athens Ballroom

Monday, February 8

1:00 PM - 1:15 PM Welcome Remarks & Keynote Lecture Introduction
James Klaunig, President - The Toxicology Forum
1:15 PM - 2:00 PM KEYNOTE LECTURE: Tobacco Product Regulation: Using Regulatory Science to Reduce Product Harm
Mitchell Zeller, Director - US FDA - Center for Tobacco Products
2:00 PM - 5:00 PM SESSION: Medium Throughput Pathway Based Alternatives to HTS for Product Stewardship
Moderated by Rebecca Clewell
2:00 PM - 2:30 PM Defining Adversity in Cell-Based Systems
Rebecca Clewell, ScitoVation, LLC
2:30 PM - 3:00 PM Addressing Metabolism and Kinetics in vitro to Improve in vitro Assay Predictions
Miyoung Yoon, ScitoVation, LLC
3:00 PM - 3:30 PM BREAK
3:30 PM - 4:00 PM Integrating Biokinetics and Biodynamics for Consumer Safety Assessment
Raja Settivari, Dow Chemical
4:00 PM - 4:30 PM Integrating Toxicokinetic and Toxicodynamic Predictive Platforms for Molecule Design
Raja Settivari, Dow Chemical
4:30 PM - 5:00 PM Moderated Panel Discussion
(Included with Registration) 


Tuesday, February 9

7:30 AM - 8:30 AM Attendee Breakfast 
(Included with Registration)
8:30 AM - 12:00 PM SESSION: E-Cigarettes: Hazard and Exposure
Moderated by A. Wallace Hayes
8:30 AM - 9:00 AM Role of e-Cigarettes in Harm-Reduction
Konstantinos Farsalinos, University of Patra 
9:00 AM - 9:30 AM Latest Approaches for 3R in the Context of Inhalation Science

Kambez Benam, Wyss Intitute - Harvard University

9:30 AM - 10:00 AM Nicotine – Delivery, Product Satisfaction, Addiction
Jed Rose, Duke University
10:00 AM - 10:30 AM BREAK
10:30 AM - 11:00 AM Liquid/Aerosol Assessment Challenges and Approaches
Julia Hoeng, PMI   
11:00 AM - 11:30 AM Regulation – Developments in the US and around the World
Gladys Erives, US FDA-CTP
11:30 AM - 12:00 PM Moderated Panel Discussion
12:00 PM - 12:30 PM Philippe Shubik Award Lecture: The Origin, Evolution and Use of Mode of Action Frameworks in Risk Assessment:  Current Practice and Future Prospects.
Award Winner: Vicki Dellarco, US EPA (Retired) 
12:30 PM - 1:30 PM Attendee Luncheon
(Included with Registration) 
1:30 PM - 5:00 PM SESSION: Human Relevant Toxicity Testing and Risk Assessment
Moderated by Kim Boekelheide
1:30 PM - 2:00 PM Human Relevant Toxicity Testing: Safety Factors or Human Tissues, Cells, and Molecules?
Kim Boekelheide, Brown University
2:00 PM - 2:30 PM Alternative Toxicity Testing of Engineered Nanomaterials: Human 3D Lung Microtissues
Agnes Kane, Brown University
2:30 PM - 3:00 PM BREAK
3:00 PM - 3:30 PM Biomarkers and High Throughput Screening Approaches for In Vitro to Animal to Human Extrapolation of Renal Toxicity
Vishal Vaidya, Harvard University Medical School
3:30 PM - 4:00 PM Application of Microphysiological Systems in Drug Discovery Toxicology
Matthew Wagoner, AstraZeneca
4:00 PM - 4:30 PM Use of Human Mechanistic Data in Regulatory Risk Assessment
Suzanne Fitzpatrick, US FDA
4:30  PM - 5:00 PM Moderated Panel Discussion
6:00 PM - 9:00 PM Attendee Dinner
(Included with Registration) 


Wednesday, February 10

7:30 AM - 8:30 AM Attendee Breakfast
(Included with Registration)
8:30 AM - 10:30 AM SESSION: Are Toxicology Training Programs Adequately Equipping the Future Leaders of Toxicology?
Moderated by Allison Greminger
8:30 AM - 9:00 AM Educating 21st Century Toxicologists: The Importance of Maintaining a Focus on the Fundamentals
Jay Goodman, Michigan State University
9:00 AM - 9:30 AM Adapting Classical Training to Emerging Tools and its Impact on Regulatory Decision Making
William Slikker, US FDA-NCTR
9:30 AM - 10:00 AM

Incorporating Tox21 and Interdisciplinary Research in Graduate Education
Kim Boekelheide & Agnes Kane, Brown University

10:00 AM - 10:30 AM Moderated Panel Discussion
10:30 AM - 11:00 AM BREAK
11:00 AM - 11:30 AM UPDATE: Endocrine Disruptor Issues and Policy Considerations: An Oil and Gas Industry Perspective
Uni Blake, American Petroleum Intstitute
11:30 AM - 12:00 PM UPDATE: Evaluating the Hazard of Exposure to Environmental Chemicals Produced Endogenously
Lynn Flowers, US EPA-ORD 
12:00 PM - 12:30 PM UPDATE: 

The Codex Alimentarius Commission’s Nutrition Committee; Recent Actions that Point the Way for Future “non-Essential” Nutrient Reference Values

James Griffiths, Council for Responsible Nutrition
12:30 PM - 1:30 PM Attendee Luncheon
(Included with Registration) 
1:30 PM - 5:00 PM SESSION: The Role of Systematic Review in Toxicology  - The Rigor, Resources, and Tools Required: Implementation Considerations for the Toxicology Community
Moderated by Craig Llewellyn & Danielle Wikoff
1:30 PM - 2:00 PM Protocol Development and Individual Study Assessment in a Systematic Review of the Health Effects of Caffeine.
Danielle Wikoff, ToxStrategies
2:00 PM - 2:30 PM Evaluation of Quantitative Scoring Approaches and Consideration of an Independent Approach 
Julie Goodman, Gradient
2:30 PM - 3:00 PM Translation of  Diagnostic Test Accuracy Guidelines to Toxicology Test Method Performance: Zebrafish Embryo Test as a Predictor of Developmental Toxicity
Katherine Tsaioun, Johns Hopkins School of Public Health - Evidence Based Toxicology Collaboration
3:00 PM - 3:30 PM BREAK
3:30 PM - 4:00 PM Dose-response Meta-analysis in Environmental Health: Arsenic Case Study
Ana Navas-Acien, Johns Hopkins School of Public Health
4:00 PM - 4:30 PM Integration of Systematic Review Methodologies in Environmental Risk Assessment
Vincent Cogliano, US EPA
 4:30 PM - 5:00 PM Moderated Panel Discussion
With Panelists: Vincent Cogliano, Suzanne Fitzpatrick, and Abee Boyles