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Determining Relevant Low-Level Chemical Exposures for Safety Assessments of Consumer Products

May 20–22, 2019

The Hotel Brussels
Brussels, Belgium
 






ADDITIONAL PRESENTATION OPPORTUNITIES REMAIN

In order to ensure that all attendees who would like to share their research can do so, the Program Committee has allocated a few additional time-slots for platform presenters. If you are still interested in attending the meeting and sharing your research, please submit your abstract today!



Abstract Submission Site



Lastly, we would like to make sure that the opportunity to present a poster is always available to you! If you would like to submit an abstract for poster presentation and share your organizations findings, methodologies, models, etc., please submit an abstract for poster presentation and be part of the dialogue.


Summary and Scope of the Workshop


Planned as a 2.5 day workshop, organized under the principles and with the assistance of The Toxicology Forum, this meeting intends to progress towards a broadly accepted framework to assess and position the safety of trace chemicals exposure from consumer products, and in particular from articles and assembled consumer goods.  Both experimental-analytical and computational approaches, and how their respective exposure data are realistic and relevant for safety assessments, will be in scope.


Workshop Scientific Program Sessions and Goals

The workshop is split into five themes that are noted below. Sessions are scheduled covering the main themes. Each session will be comprised of a mix of invited keynote speakers, with the remaining slots determined through an open call for presentation opportunity for all interested participants.  The workshop should allow for different stakeholders with potentially opposing views to present their opinion and lead to a constructive scientific debate.



Click Here to View the Detailed Meeting Agenda



The agenda is organized to give attendees an overview of the scheduled presentations and an overview of the meeting structure so that they may plan their days. The flow of the meeting is intended to promote understanding and learning from each presenter to build a common base of knowledge for all attendees so that the central questions of the meeting can be addressed by everyone.

 




Topic #1: Advances in Analytical Methods: How to Detect and Quantify Relevant Low-Level Chemical Exposure from All Routes?

  • Novel methods for specific constituents and contaminants
  • Detecting and quantifying IAS and NIAS
  • Test set up that closely mimics in-use exposure (dermal/inhalation/oral)
  • Matrix effects
  • Extractables and leachables from poorly studied/documented consumer goods and materials
  • NIAS and substances formed in situ
  • Analytical methods for bio-monitoring
  • Approaches for ensuring accuracy and understanding limitations/uncertainties with low-level exposure testing

Topic #2: Experimental and/or Modeling Approaches?

  • Use and limitations of both approaches
  • Frameworks that combine analytical work with modeling
  • High-throughput approaches
  • Advances in exposure modeling and validation
  • Extraction media/conditions for physiologically relevant extractions
  • Proposals for standardized test design and set up
  • Sectoral views & Supply chain analysis

Topic #3: Global Databases for Exposure Information

  • Public exposure databases and initiatives in different geographies – what’s available?
  • Harmonization of information and formats
  • Use of large datasets for population modelling
  • Obtaining more data from industry

Topic #4: Guidance for Practitioners, Recommendations for Policy Work and Public Communication

  • Consumer perception of information on chemical presence (trend for organics/naturals/’chemical-free’)
  • Risk versus hazard communication
  • Information and transparency requirements for industry on presence of chemicals
  • Media guidance

Topic #5: Towards a Risk Assessment Best Practice Framework

 


Registration

Registration for the meeting is currently open. Please use the online system linked to below in order to register for the meeting. A brief breakdown of registration prices appears below. The registration fee includes access to all meeting sessions, meals, receptions, etc. scheduled during the meeting. Please contact Kevin Merritt with any questions or concerns regarding meeting registration.

CLICK HERE FOR ONLINE MEETING REGISTRATION

Registration Rates: (Rates in parentheses reflect pricing after the early registration deadline of April 20, 2019)

Member: $600 / ($700)
Nonmember (Gov., Academic, Non-Profit): $850 / ($1000)
Nonmember (Corporate): $1100 / ($1400)
Speaker (non-Invited): $350
Student/Postdoc: $100 / ($150)


Sponsorship

View more info and become a sponsor!

This meeting is made possible by the financial contributions of sponsoring companies. A complete list of sponsors appears below. In addition to registration discounts, marketing opportunities, and increased awareness of your companies products and services, sponsoring the meeting helps to ensure future viability of meetings of this nature, granting a continued venue for dialogue and interaction in this facet of science!

Current Sponsors

European Chemical Industry Council—Long-Range Research Initiative

ExxonMobil Biomedical Sciences, Inc.

PepsiCo

The Coca-Cola Company

Procter & Gamble Company


Housing Reservations

Click Here to Reserve Now!

Housing for the meeting is now open. The Toxicology Forum has reserved a limited blocked of discounted rooms for meeting attendees. Reservations are booked based on a first come first served basis. Please visit the Brussels Meeting Housing Reservations page for additional information on rates and booking.

Things to Do in Brussels

Whether it be the must-see museums and art galleries, the unmissable guided city tours, the chic and luxurious shopping district, the exquisite beer selections, or the decadent local chocolatiers, Brussels has something for everyone! Don't miss your opportunity to explore the city and all it has to offer. Please visit the Brussels Convention and Visitor's Bureau website, Visit Brussels, for more information and inspiration.


Workshop Background and Importance

Increasingly, toxicologists in both industry and regulatory agencies are challenged to address low-level exposures to chemicals in consumer products. While there have been significant advances in the area of exposure assessment, and some widely recognized frameworks exist (such as those used to evaluate the potential for packaging chemicals to migrate into food, or for building material and medical devices), there are currently no broadly accepted methods for evaluating and quantifying potential consumer exposure from several other consumer products such as textiles, toys, furniture, absorbent hygiene products. Having a basic framework recognized by the global scientific community will provide clarity and transparency in how ‘best practice’ exposure assessments are to be done.

Manufacturers of consumer products are regularly requested to share information on the compounds contained in their products, including providing assurance that certain ingredients and contaminants are not present.  Also the increased use of recyclates in support of a ‘circular economy’ may increasingly trigger such questions.  This can result in significant challenges for complex formulations/products, especially for chemicals that are not intentionally added (NIAS), or were not disclosed as contaminants by suppliers, but nonetheless could be found when non-physiological extraction and sensitive analytical methods are employed.

Quantifying relevant exposure associated with use of a range of products, and especially solid articles, can require advanced sampling approaches and analytical capability that reasonably mimic those conditions that might occur with actual and foreseeable consumer use. By contrast, some regulatory schemes make extensive use of in-silico (computational) approaches to perform a screening risk assessment. This also raises the question of how analytical and mathematical modelling data can be compared or combined. For both approaches it should also be better defined what are ‘most realistic’, ‘reasonably conservative’ versus ‘exaggerated’ or ‘not practically relevant’ conditions.


Who Should Attend and Participate

Individuals involved in quality assurance, analytical, and safety experts from chemical suppliers and producers of consumer good and articles, regulators involved consumer exposure and public health topics, academic experts in exposure and analytical chemistry, contract laboratories, exposure modelers, those interested in risk assessment, risk management, mode-of-action, and/or human relevance of analytical exposure measurements.  We also welcome the participation of NGOs and consumer associations, science journalists and social science experts. 

Meetings of The Toxicology Forum are open to all interested participants. 


Products and Materials in Scope

The workshop organizers recognize that certain product categories such as medical devices and foods contact materials already have a great deal of guidance and practice associated them.  The  organizers hope to address in particular those categories where frameworks are currently less developed or non-existing. These will include; electric/electronic equipment and appliances, household and personal care products, home improvement products, air fresheners, clothes/fabrics/textiles, furniture, toys, 3D-printing materials, recyclates.


 

Organizing Committee

The organizing committee is comprised of a number of individuals from the United States and the European Union representing government, academia, and industry.

View Committee Member Biosketches

John Bartzis, PhD
University of Western Macedonia

Greece

Silvia Campos, MSc
The Coca Cola Company
Belgium
Wolfgang Dekant, PhD
University of Wuerzburg
Germany
Kathie Dionisio, ScD
US EPA
United States

Suzanne Fitzpatrick, PhD, DABT, ERT
US FDA/CFSAN
United States

Eddy Goelen, MS
VITO
Belgium
Bruno Hubesch, PhD
CEFIC
Brussels, Belgium
Kristin Isaacs, PhD
US EPA

United States
Stylianos Kephalopoulos, PhD
European Commission

Italy
Pim Leonards, PhD
Free University Amsterdam
Netherlands
Marusia Popovech, PhD, MPH
ExxonMobil Biomedical Sciences
United States
Amy Roe, PhD, DABT
Procter & Gamble (USA)
United States
Diederik Schowanek, PhD
Procter & Gamble (BE)
Belgium (Chair)
John Wambaugh, PhD
US EPA
United States

Jeff